MMP-14 is necessary but not sufficient for invasion of three-dimensional collagen by human muscle satellite cells

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MMP-14 is necessary but not sufficient for invasion of three-dimensional collagen by human muscle satellite cells.

The twenty-five known matrix metalloproteases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteases (TIMPs), mediate cell invasion through the extracellular matrix (ECM). In a comparative three-dimensional assay, we analyzed human and mouse satellite cells' competence to invade an artificial ECM (collagen I). We identified a single MMP that 1) is expressed by human muscl...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Cell Physiology

سال: 2014

ISSN: 0363-6143,1522-1563

DOI: 10.1152/ajpcell.00032.2014